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Clin Calcium. 2003 Jun;13(6):687-93.

[Inflammatory cytokines and bone diseases].

[Article in Japanese]

Author information

1
Department of Orthopaedic Surgery and Rheumatology, Nara Hospital, Kinki University School of Medicine.

Abstract

The abnomalities in cytokines may be an pathogenetic factor in human diseases as diverse as rheumatoid arthritis (RA), some bone diseases, multiple myeloma, metastatic bone tumors. A cytokine imbalance in favour of pro-inflammatory mediators may be a central pathogenic mechanism in RA. Pro-inflammatory mediators include the cytokines TNF-alpha and IL-1, which activate osteoclasts to resorb subchondral bone. A further important mediator is the recently described osteoclast differentiation factor (ODF) (also reffered to as TNF-related activation-induced cytokine [TRANCE], receptor activator of nuclear factor kappaB ligand [RANKL], or osteoprotegerin ligand).

PMID:
15775137
DOI:
CliCa0306687693

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