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J Bacteriol. 2005 Apr;187(7):2540-50.

Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis.

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1
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore-560012, India.

Abstract

Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.

PMID:
15774900
PMCID:
PMC1065227
DOI:
10.1128/JB.187.7.2540-2550.2005
[Indexed for MEDLINE]
Free PMC Article
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