Format

Send to

Choose Destination
Altern Med Rev. 2005 Mar;10(1):36-41.

Hormone replacement with estradiol: conventional oral doses result in excessive exposure to estrone.

Author information

1
Steroids Department, Meridian Valley Laboratory, 801 SW 16th, Suite 126, Renton, WA 98055, USA. steroids@meridianvalleylab.com

Abstract

BACKGROUND:

There is a lack of consensus about the safety of estrogen replacement therapy, especially with regard to its impact on a woman's risk for breast cancer. Elevated urinary or serum estrone and estradiol concentrations in postmenopausal women are associated with a moderately elevated risk of breast cancer.

METHODS:

Twenty-four-hour urinary steroid hormone profiles, including the measurement of estrone, estradiol, and estriol, were conducted for 35 postmenopausal women receiving oral estradiol at doses from 0.025-2.0 mg/day.

RESULTS:

Urinary excretion of estradiol exceeded premenopausal reference range values in women taking estradiol at doses greater than 0.5 mg/day. Urinary estrone excretion exceeded premenopausal reference range values in women taking estradiol doses of 0.25 mg/day or higher. Literature data indicate serum estrone concentrations also markedly exceed premenopausal reference ranges when estradiol is administered orally at a dose of 1 mg/day.

CONCLUSIONS:

The previously recommended oral dose of estradiol (1-2 mg/day) results in urinary excretion of estrone at values 5-10 times the upper limit of the reference range for premenopausal women. Retrospective studies associating oral estradiol with increased risk of breast cancer may reflect overdose conditions. Based on current knowledge, a prudent dose ceiling for oral estradiol replacement therapy of 0.25 mg/day is proposed.

PMID:
15771561
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Alternative Medicine Review
Loading ...
Support Center