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J Am Chem Soc. 2005 Mar 23;127(11):3686-7.

Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides.

Author information

1
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Abstract

We have used our ability to control beta-peptide secondary structure in order to explore the effects of conformational stability and geometry of guanidinium display on cell entry. Both of these factors affect the rate and relative amount of beta-peptide accumulation in the cytoplasm and nucleus of live HeLa cells. These beta-peptides do not show significant differences in cell surface binding, implying that structure and guanidinium display are important in a later step in cell entry than initial surface binding.

PMID:
15771489
DOI:
10.1021/ja042566j
[Indexed for MEDLINE]

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