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J Med Chem. 2005 Mar 24;48(6):1910-8.

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

Author information

1
Center for Molecular Design, Janssen Pharmaceutica, Antwerpsesteenweg 37, B-2350 Vosselaar, Belgium. jheeres@prdbe.jnj.com

Abstract

A series of novel pyrazinones designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs) was synthesized and their anti-HIV structure-activity relationship (SAR) was studied.

PMID:
15771435
DOI:
10.1021/jm040829e
[Indexed for MEDLINE]

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