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J Med Chem. 2005 Mar 24;48(6):1709-12.

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

Author information

1
Johnson & Johnson Pharmaceutical Research & Development, Drug Discovery CNS; Jarama 75, 45007 Toledo, Spain. jfernan0@prdes.jnj.com

Abstract

A series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, alpha-adrenergic, and histamine receptors and for the norepinephrine transporter as well as the ED(50) values obtained in some in vivo assays for antipsychotic, anxiolytic, and antidepressant potential are reported. Compounds (-)-1, (-)-8d, and (+)-8d have been identified as potential broad-spectrum psychotropic agents.

PMID:
15771415
DOI:
10.1021/jm049632c
[Indexed for MEDLINE]

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