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C R Biol. 2005 Feb;328(2):187-98.

Anticipating epileptic seizures: from mathematics to clinical applications.

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Laboratoire de Neurosciences Cognitives et Imagerie Cérébrale, LENA, CNRS UPR 640, Hôpital de la Pitié-Salpêtrière, 47, bd de l'Hôpital, 75651 Paris, France.


The study of dynamical changes in the neural activity preceding an epileptic seizure allows the characterization of a preictal state several minutes prior to seizure onset. This opens new perspectives for studying the mechanisms of ictogenesis as well as for possible therapeutic interventions that represent a major breakthrough. In this review we present and discuss the results from our group in this domain using nonlinear analysis of brain signals, as well as its limitation and open questions.

[Indexed for MEDLINE]

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