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Australas Psychiatry. 2005 Mar;13(1):72-5.

Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa.

Author information

1
Peter Beumont Eating Disorder Service, Ashfield, NSW, Australia. naresh.mondraty@wesleymission.org.au

Abstract

OBJECTIVE:

Recovery from anorexia nervosa is confounded by intrusive anorectic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role.

METHODS:

A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine.

RESULTS:

Only the olanzapine group had a significant reduction in the degree of rumination.

CONCLUSION:

Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.

[Indexed for MEDLINE]

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