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Front Biosci. 2005 May 1;10:1135-45.

Transforming growth factor -beta receptor signaling in cancer.

Author information

1
Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA. snarayan@ufscc.ufl.edu <snarayan@ufscc.ufl.edu>

Abstract

Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types. The TGF-beta ligand initiates signaling by binding to and joining type I and II receptors of serine/threonine kinases. This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression.

PMID:
15769612
DOI:
10.2741/1606
[Indexed for MEDLINE]

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