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Chromosoma. 1992 Mar;101(5-6):259-64.

Integrating chromosome structure with function.

Author information

1
Department of Anatomy and Medical Biochemistry, University of Calgary, Alberta, Canada.

Abstract

Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.

PMID:
1576878
DOI:
10.1007/bf00346003
[Indexed for MEDLINE]

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