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J Virol. 2005 Apr;79(7):4510-3.

Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7.

Author information

1
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.

Abstract

Antigen-experienced T cells have been divided into CD62L+ CCR7+ central memory (TCM) and CD62L- CCR7- effector memory (TEM) cells. Here, we examined coexpression of CD62L and CCR7 in lymphocytic choriomeningitis virus-specific memory CD8 T cells from both lymphoid and nonlymphoid tissues. Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L- CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; and thirdly, a major shift from a TCM to TEM phenotype was found in memory cells that had been stimulated repetitively with antigen.

PMID:
15767451
PMCID:
PMC1061544
DOI:
10.1128/JVI.79.7.4510-4513.2005
[Indexed for MEDLINE]
Free PMC Article

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