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J Clin Invest. 2005 Mar;115(3):572-83.

Unchain my heart: the scientific foundations of cardiac repair.

Author information

1
Department of Molecular Cardiology, University of Frankfurt, Frankfurt am Main, Germany. Dimmeler@em.uni-frankfurt.de

Abstract

In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative--to offset cell death in acute ischemic injury and chronic heart failure--and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.

PMID:
15765139
PMCID:
PMC1052009
DOI:
10.1172/JCI24283
[Indexed for MEDLINE]
Free PMC Article

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