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J Clin Invest. 2005 Mar;115(3):556-64.

Altered intracellular Ca2+ handling in heart failure.

Author information

1
Department of Medical Bioregulation, Division of Cardiovascular Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan.

Abstract

Structural and functional alterations in the Ca2+ regulatory proteins present in the sarcoplasmic reticulum have recently been shown to be strongly involved in the pathogenesis of heart failure. Chronic activation of the sympathetic nervous system or of the renin-angiotensin system induces abnormalities in both the function and structure of these proteins. We review here the considerable body of evidence that has accumulated to support the notion that such abnormalities contribute to a defectiveness of contractile performance and hence to the progression of heart failure.

PMID:
15765137
PMCID:
PMC1052007
DOI:
10.1172/JCI24159
[Indexed for MEDLINE]
Free PMC Article

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