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J Clin Invest. 2005 Mar;115(3):547-55.

Mitochondrial energy metabolism in heart failure: a question of balance.

Author information

1
Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Abstract

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.

PMID:
15765136
PMCID:
PMC1052011
DOI:
10.1172/JCI24405
[Indexed for MEDLINE]
Free PMC Article

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