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J Clin Invest. 2005 Mar;115(3):509-17.

NO/redox disequilibrium in the failing heart and cardiovascular system.

Author information

1
Johns Hopkins University School of Medicine, Department of Medicine, Cardiology Division, Baltimore, Maryland 21205, USA. jhare@mail.jhmi.edu

Abstract

There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.

PMID:
15765132
PMCID:
PMC1052013
DOI:
10.1172/JCI24459
[Indexed for MEDLINE]
Free PMC Article

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