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Scand J Infect Dis. 2004;36(11-12):829-31.

In vitro inhibition of SARS virus replication by human interferons.

Author information

1
Swedish Institute for Infectious Disease Control, Stockholm, Sweden. Helena.Dahl@smi.ki.se

Abstract

Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.

PMID:
15764169
DOI:
10.1080/00365540410021144
[Indexed for MEDLINE]

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