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Platelets. 2005 Feb;16(1):61-2.

Platelet refractoriness to classical agonists in a child with essential thrombocythemia.

Author information

1
Autonomous University of Nuevo Leon, Monterrey, Mexico. carjaime@hotmail.com

Abstract

BACKGROUND:

Essential thrombocythemia is a rare disease during childhood. Platelet morphological abnormalities are frequent and defects in platelet function tests, mainly hypoaggregation, occur.

MATERIALS AND METHODS:

An incidental diagnosis of essential thrombocythemia was established in a 9-year-old boy with a platelet count of 2050 x 10(9)/l. His platelets were studied for aggregation defects with four classical agonists employing optical aggregometry.

RESULTS:

Aggregation ranged from 5% for adrenaline, 8% for collagen, 12% for ristocetin, to 25% with adenosine diphosphate, followed by complete disaggregation.

CONCLUSION:

Platelet refractoriness to classical agonists, probably compounded by platelet GPIb deficiency, was documented. The differential diagnosis is discussed.

PMID:
15763898
DOI:
10.1080/09537100400007424
[Indexed for MEDLINE]

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