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FEBS Lett. 2005 Mar 21;579(8):1854-8.

Structure-based systems biology: a zoom lens for the cell.

Author information

1
EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. aloy@embl.de

Abstract

Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins.

PMID:
15763563
DOI:
10.1016/j.febslet.2005.02.014
[Indexed for MEDLINE]
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