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FEBS Lett. 2005 Mar 21;579(8):1821-7.

From protein networks to biological systems.

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Research Center Karlsruhe, Institute of Genetics, P.O. Box 3640, D-76021 Karlsruhe, Germany.


A system-level understanding of any biological process requires a map of the relationships among the various molecules involved. Technologies to detect and predict protein interactions have begun to produce very large maps of protein interactions, some including most of an organism's proteins. These maps can be used to study how proteins work together to form molecular machines and regulatory pathways. They also provide a framework for constructing predictive models of how information and energy flow through biological networks. In many respects, protein interaction maps are an entrée into systems biology.

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