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J Neurosci Methods. 2005 Apr 15;143(1):41-7. Epub 2004 Nov 28.

Unraveling neuronal dopamine transporter mechanisms with rotating disk electrode voltammetry.

Author information

  • 1Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA. geni@wsu.edu

Abstract

Herein we describe how the rotating disk electrode voltammetric technique can be used to examine the mechanism(s) of the inward transport of dopamine by the neuronal transporter for dopamine (DAT). The usefulness of making measurements kinetically resolving dopamine transport, interpretations of changes in Km and Vmax, approaches to defining pre-steady-state binding of dopamine to DAT, interactions between competing inhibitors, chemical modification of functional groups within DAT, and a presentation of a hypothetical multi-state model of dopamine transport are presented and discussed.

PMID:
15763135
DOI:
10.1016/j.jneumeth.2004.09.021
[PubMed - indexed for MEDLINE]
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