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AJNR Am J Neuroradiol. 2005 Mar;26(3):447-54.

Myelination in children with partial deletions of chromosome 18q.

Author information

1
Research Imaging Center, University of Texas Health Science Center at San Antonio, TX 78284, USA.

Abstract

BACKGROUND AND PURPOSE:

We compared myelin levels in white matter (WM) in typically developing children with those of children with partial deletions of chromosome 18q (18q-).

METHODS:

Conventional spin-echo MR imaging at 1.9T was used to acquire T1-, T2-, and proton density-weighted images of the brain. From these images, a three-pool model was used to estimate the fraction of water in myelin, myelinated axon, and mixed water compartments (or pools) in six WM regions. A model curve was fit to the pool fractions to model the trend of myelin development by age in each region. Water-pool fractions in children with 18q- aged 5 months to 13 years were compared with those of age-matched, typically developing children.

RESULTS:

In children with 18q-, the model predicted later onset of myelination (P <.02), lower myelination rates (P <.001), and smaller equilibrium myelin pool fractions (P <.001). Significant differences were seen between the two groups for all three water pool fractions (P <.001). The mixed pool fraction was larger in children with 18q-. Although the myelin pool fraction was significantly smaller, the myelinated axon pool fraction was only slightly smaller, leading to a significantly smaller estimate of myelin per myelinated axon in children with 18q- (P <.001).

CONCLUSION:

Myelination modeling in 18q- children indicated delayed onset, a lower rate of myelination, and equilibrium myelin levels less than 50% those of age-matched, typically developing children.

PMID:
15760848
[Indexed for MEDLINE]
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