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Endocr Pract. 2004 Sep-Oct;10(5):424-8.

Ectopic adrenocorticotropic hormone hypersecretion due to a primary pulmonary paraganglioma.

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1
Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Abstract

OBJECTIVE:

To present a rare case of primary paraganglioma of the lung, which caused the syndrome of ectopic adrenocorticotropic hormone (ACTH) hypersecretion.

METHODS:

The clinical, biochemical, and imaging findings in this case are described, and the pathologic features of the resected tumor tissue are depicted. In addition, the related literature on paragangliomas is reviewed.

RESULTS:

In a 39-year-old woman with hypertension, weight gain, and easy bruising, laboratory studies showed hypercortisolemia, high plasma ACTH levels, and suppression of cortisol by high-dose dexamethasone. An indium-labeled octreotide whole-body scan disclosed a tumor in the left lower lung field. Thoracoscopic wedge resection of the pulmonary mass was performed. Postoperative microscopic findings and immunohistochemical stains revealed nests of rounded and polyhedral cells and S-100 protein-positive sustentacular (supporting) cells, charac-

CONCLUSION:

This unusual case of Cushing's syndrome was attributable to an ACTH-secreting primary pulmonary paraganglioma.

PMID:
15760790
DOI:
10.4158/EP.10.5.424
[Indexed for MEDLINE]
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