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Biochem Biophys Res Commun. 1992 Apr 30;184(2):568-75.

Downstream region of the human tyrosinase-related protein gene enhances its promoter activity.

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  • 1Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.


We have cloned and sequenced the human genomic DNA segments encoding the 5'-flanking region and the first two exons of the tyrosinase-related protein (TRP) gene, a pigment cell-specific gene. Functional analysis of its promoter suggests that the downstream region of the TRP gene, including the first intron, enhances the transient expression of the luciferase gene under control of the TRP gene promoter about 16- to 20-fold. This enhancer-like activity is detected not only in melanoma cells but also in HeLa cells whose TRP gene expression is assumed to be repressed. We suggest a possibility that the downstream region is not sufficient to confer pigment cell-specific expression, but is required for efficient transcription of the TRP gene in pigment cells.

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