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Bioessays. 1992 Feb;14(2):105-11.

Accessory protein function in the DNA polymerase III holoenzyme from E. coli.

Author information

1
Howard Hughes Medical Institute, Microbiology Department, Cornell University Medical College, NY 10021.

Abstract

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

PMID:
1575709
DOI:
10.1002/bies.950140206
[Indexed for MEDLINE]

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