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J Pediatr. 2005 Mar;146(3):423-5.

Fatal varicella associated with selective natural killer cell deficiency.

Author information

1
Meyer Children's Hospital, Department of Immunology, B. Rappaport Medical School, Technion, Haifa, Israel. etzioni@rambam.health.gov.il

Abstract

A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection.

PMID:
15756234
DOI:
10.1016/j.jpeds.2004.11.022
[Indexed for MEDLINE]

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