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Ann Pharmacother. 2005 Apr;39(4):727-31. Epub 2005 Mar 8.

Pharmacologic treatment of opioid-induced sedation in chronic pain.

Author information

1
Pain Management, Akron General Medical Center, Akron, OH 44398-7191, USA. jreissig@agmc.org

Abstract

OBJECTIVE:

To review the literature for pharmacologic management of opioid-induced sedation (OIS) in patients with chronic pain.

DATA SOURCES:

A search of MEDLINE (1966-October 2004) for English-language literature and selected bibliographies was completed. Search terms included pain, opioid, sedation, psychostimulants, amphetamines, modafinil, and donepezil.

DATA SYNTHESIS:

Amphetamines and amphetamine-like agents, caffeine, donepezil, and modafinil have been evaluated for OIS. Available literature is limited by numbers of subjects, duration, and trial design; however, there is limited support for the use of methylphenidate, donepezil, and modafinil.

CONCLUSIONS:

Pharmacologic treatment of OIS should be utilized selectively, given the available literature. Methylphenidate, donepezil, and modafinil may be considered in appropriate patients.

PMID:
15755795
DOI:
10.1345/aph.1E309
[Indexed for MEDLINE]

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