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Vaccine. 2005 Mar 18;23(17-18):2078-81.

The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program.

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Mayo Vaccine Research Group, and Department of Medicine, Program in Translational Immunovirology and Biodefense, 611 C Guggenheim Building, 200 First Street, SW, Mayo Clinic and Foundation, Rochester, Minnesota, MN, USA.


We describe the US experience with a large-scale smallpox vaccination program in the modern era and quantify the anticipated and unanticipated local and systemic side-effects of smallpox vaccination. In addition, we review unexpected issues, such as the development of myopericarditis discovered during the implementation of this program. These results constitute the largest dataset of a vaccinia vaccination program utilizing calf-lymph derived New York City Board of Health strain vaccine (Dryvax, Wyeth) since the 1970s. These results should inform current and future vaccinia vaccination programs and provide a historical rate of complications against which candidate vaccine side-effects can be compared in future clinical trials.

[Indexed for MEDLINE]

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