Distribution of CCR5-delta32, CCR2-64I, and SDF1-3'A mutations in populations from the Brazilian Amazon region

Fernanda Andreza De Pinho Lott Carvalhaes; Greice Lemos Cardoso; Igor Guerreiro Hamoy; Yan Tat Liu; João Farias Guerreiro

doi:10.1353/hub.2004.0052

Distribution of CCR5-delta32, CCR2-64I, and SDF1-3'A mutations in populations from the Brazilian Amazon region

Hum Biol. 2004 Aug;76(4):643-6. doi: 10.1353/hub.2004.0052.

Authors

Fernanda Andreza De Pinho Lott Carvalhaes¹, Greice Lemos Cardoso, Igor Guerreiro Hamoy, Yan Tat Liu, João Farias Guerreiro

Affiliation

¹ Laboratory of Human and Medical Genetics, Department of Pathology, Center for Biological Sciences, Federal University of Pará, 66075-900 Belém, Para, Brazil.

PMID: 15754978
DOI: 10.1353/hub.2004.0052

Abstract

The frequency distribution of the CCR5-delta32, CCR2-64I, and SDF1-3'A alleles was studied in the urban population of Belém and in Afro-Brazilians, Amerindians, and Japanese immigrants in the state of Pará, Brazil. The results suggest that Amerindians may be genetically more susceptible to HIV-1 infection and disease progression than the other human groups studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Black People / genetics
Brazil
Chemokines / genetics
Disease Progression
Gene Frequency*
Genetic Predisposition to Disease / ethnology*
Genetics, Population*
Genotype
HIV-1 / genetics
Humans
Indians, South American / genetics
Japan / ethnology
Mutation
Polymorphism, Restriction Fragment Length*
Receptors, CCR5 / genetics*

Substances

Chemokines
Receptors, CCR5