Format

Send to

Choose Destination
J Zhejiang Univ Sci B. 2005 Apr;6(4):265-71.

Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat.

Author information

1
Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. heavenbird_l@hotmail.com

Abstract

In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of delta1 and delta2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased beta2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitory effects.

PMID:
15754424
PMCID:
PMC1389735
DOI:
10.1631/jzus.2005.B0265
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Zhejiang University Press Icon for PubMed Central
Loading ...
Support Center