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Br J Clin Pharmacol. 2005 Mar;59(3):298-301.

The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

Author information

1
School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea. hombanfr@upng.ac.pg

Abstract

AIMS:

We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria.

METHODS:

AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method.

RESULTS:

AQ was not detectable beyond day 3 postdose. Cmax for DEAQ was reached in 3.0 days. The mean values for t1/2, MRT, and AUCtotal were 10.1 days, 15.5 days and 4512.6 microg l(-1) day, respectively. All the children were CYP2C8* homozygous.

CONCLUSION:

Our data are consistent with those previously reported, and the AQ regimen seems pharmacokinetically adequate in the absence of CYP2C8 polymorphism.

PMID:
15752375
PMCID:
PMC1884785
DOI:
10.1111/j.1365-2125.2004.02257.x
[Indexed for MEDLINE]
Free PMC Article

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