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Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6.

The structural basis of blebbistatin inhibition and specificity for myosin II.

Author information

1
Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA.

Abstract

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

PMID:
15750603
DOI:
10.1038/nsmb908
[Indexed for MEDLINE]

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