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J Histochem Cytochem. 2005 Mar;53(3):297-9.

Analysis of cell-free fetal DNA in plasma and serum of pregnant women.

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  • 1Research Centre for Medical Genetics, Prenatal Diagnosis, Russian Academy of Medical Sciences, Moskvorechje 1, Moscow 115478, Russia.


Sixty blood samples from pregnant women during gestational weeks 9-28 were investigated. Cell-free fetal DNA was extracted from maternal plasma or serum to be detected by nested PCR for determination of fetal gender. The SRY gene as a marker for fetal Y chromosome was detected in 34/36 women carrying a male fetus. In 3/24 women carrying female fetuses, the SRY sequence was also detected. Overall, fetal sex was correctly predicted in 91.7% of the cases. Therefore, the new, non-invasive method of prenatal diagnosis of fetal gender for women at risk of producing children with X-linked disorders is reliable, secure, and can substantially reduce invasive prenatal tests.

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