Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2005 Mar;28(3):145-51.

Orchestrating time: arrangements of the brain circadian clock.

Author information

1
Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. antlem@ucalgary.ca

Abstract

Daily oscillations in physiology and behavior are regulated by a brain clock located in the suprachiasmatic nucleus (SCN). Individual cells within this nucleus contain an autonomous molecular clock. Recent discoveries that make use of new molecular and genetic data and tools highlight the conclusion that the SCN is a heterogeneous network of functionally and phenotypically differentiated cells. Neurons within SCN subregions serve distinctly separate functions in regulating the overall activity of the circadian clock: some cells within the SCN rhythmically express "clock" genes, whereas others exhibit induced expression of these genes after the organism has been exposed to a light pulse. The coordinated interaction of these functionally distinct cells is integral to the coherent functioning of the brain clock.

PMID:
15749168
DOI:
10.1016/j.tins.2005.01.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center