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Neuron. 2005 Mar 3;45(5):642-4.

Courting a cure for fragile X.

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1
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.

PMID:
15748838
DOI:
10.1016/j.neuron.2005.02.021
[Indexed for MEDLINE]
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