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Clin Chim Acta. 2005 Apr;354(1-2):35-40. Epub 2005 Jan 13.

Autoantibodies in Type 1 diabetes.

Author information

1
Department of Diabetes and Metabolism, Institute of Cell and Molecular Science, St. Bartholomew's Hospital, London EC1A 7BE, United Kingdom.

Abstract

BACKGROUND:

Autoimmune diseases are associated with autoantibodies which recognise specific antigens.

METHODS:

Autoantibodies can be detected by various methods including immunofluorescence and radioimmunoassays using disease-specific radiolabelled recombinant autoantigens As recombinant assay have high-throughput potential, it is now even possible to screen whole populations.

RESULTS:

Diabetes-associated autoantibodies including autoantibodies to glutamic acid decarboxylase are valuable in disease classification and disease prediction. Some autoantibodies are more predictive of diabetes than others.

CONCLUSIONS:

Autoantibodies, and the antigens they recognise, are potentially valuable in the prediction and prevention respectively of type 1 diabetes as well as in the classification of autoimmune diabetes. Screening the general population for type 1 diabetes susceptibility is now feasible. Trials to prevent type 1 diabetes using disease-associated autoantigens are now in progress.

PMID:
15748597
DOI:
10.1016/j.cccn.2004.11.017
[Indexed for MEDLINE]

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