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Acta Otorrinolaringol Esp. 2005 Jan;56(1):1-5.

[The effect of AM3 in the resolution of otitis media with effusion (OME) in paediatric patients].

[Article in Spanish]

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Servicio de Otorrinolaringología, Hospital General de Móstoles, Móstoles, Madrid.



Otitis media with effusion (OME) is one of the most frequent diseases and the main cause of hearing loss in childhood. The medical treatment for OME includes antibiotics, antihistamine-decongestant combinations, steroids and Eustachian-tube autoinflation as the Valsalva manoeuvre.


A total of 62 children aged 2 to 8 years with a diagnosis of OME were enrolled in a prospective study to assess the resolution of OME. Patients were given antibiotics treatment with or without associated AM3.


After 2 months of treatment, the rate of complete resolution of OME was greater in AM3 treated group than in the non-AM3 treated group (57.6% vs 27.6%) with a statistically significant difference (p<0.017).


These results show that AM3 treatment has a beneficial effect on OME resolution when it is associated to antibiotic treatment.

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