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Bioorg Med Chem Lett. 2005 Mar 15;15(6):1749-53.

Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists.

Author information

1
Athersys, Inc., Medicinal Chemistry, 3201 Carnegie Avenue, Cleveland, OH 44115-2634, USA. mrobarge@athersys.com

Abstract

The chemoattractant receptor-homologous molecule expressed on T(H)2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D2 receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.

PMID:
15745833
DOI:
10.1016/j.bmcl.2004.12.055
[Indexed for MEDLINE]
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