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Bioorg Med Chem Lett. 2005 Mar 15;15(6):1587-90.

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

Author information

1
Pfizer Global Research and Development, 700 Chesterfield Parkway W, Chesterfield, MO 63017, USA. david.r.anderson@pfizer.com

Abstract

A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFalpha in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported.

PMID:
15745802
DOI:
10.1016/j.bmcl.2005.01.067
[Indexed for MEDLINE]

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