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Retrovirology. 2005 Mar 2;2:17.

The discovery of the first human retrovirus: HTLV-1 and HTLV-2.

Author information

1
Institute of Human Virology University of Maryland Biotechnology Institute 701 E, Pratt Street Baltimore, MD 21202, USA. gallo@umbi.umd.edu

Abstract

I describe here the history leading up to and including my laboratory's discovery of the first human retrovirus, HTLV-I, and its close relative, HTLV-II. My efforts were inspired by early work showing a retroviral etiology for leukemias in various animals, including non-human primates. My two main approaches were to develop criteria for and methods for detection of viral reverse transcriptase and to identify growth factors that could support the growth of hematopoietic cells. These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma/leukemia cells.

PMID:
15743526
PMCID:
PMC555587
DOI:
10.1186/1742-4690-2-17
[Indexed for MEDLINE]
Free PMC Article

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