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Eur J Clin Nutr. 2005 Apr;59(4):592-6.

Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus.

Author information

1
Department of Human Nutrition, Faculty of Nutrition and Food Technology; Shahid Beheshtee University of Tehran, Tehran, Iran. ar.r@scientist.com

Abstract

OBJECTIVE:

We designed this study to investigate the effects of oral L-carnitine administration on fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and lipid parameters in patients with diabetes mellitus type II.

PATIENTS AND METHODS:

The effect of L-carnitine on FPG and lipid parameters was investigated in 22 male and 13 female type II diabetic patients; the mean age +/- s.d. was 51.3 +/- 3.7 y. The patients were randomly allocated to two groups (L-carnitine and placebo group) and 1 g of L-carnitine or of placebo was given orally three times a day for a period of 12 weeks.

RESULTS:

FPG in the L-carnitine group decreased significantly from 143 +/- 35 to 130 +/- 33 mg/dl (P = 0.03), and we observed a significant increase of triglycerides (TG) from 196+/-61 to 233+/-12 mg/dl (P = 0.05), of Apo A1 from 94 +/- 20 to 103 +/- 23 mg/dl (P = 0.02), and of Apo B100 from 98 +/- 18 to 108 +/- 22 mg/dl (P = 0.02) after 12 weeks of treatment. There was no significant change in LDL-C, HDL-C, HbA1C, LP(a) or total cholesterol.

CONCLUSION:

L-Carnitine significantly lowers FPG but increases fasting triglyceride in type II diabetic patients.

PMID:
15741989
DOI:
10.1038/sj.ejcn.1602109
[Indexed for MEDLINE]

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