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J Am Chem Soc. 2005 Mar 9;127(9):2937-43.

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

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  • 1Institut für Chemie der Freien Universität Berlin, Takustrasse 6, 14195 Berlin, Germany.


The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.

[PubMed - indexed for MEDLINE]
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