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J Invest Dermatol. 2005 Mar;124(3):481-92.

Transglutaminase function in epidermis.

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Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio 44106, USA.


Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.

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