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Cell. 2005 Feb 25;120(4):533-44.

Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.

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1
UCSD Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California 92093, USA. kchien@partners.org

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  • Cell. 2005 Apr 8;121(1):153-4.

Abstract

Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.

PMID:
15734685
DOI:
10.1016/j.cell.2005.02.006
[Indexed for MEDLINE]
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