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J Am Soc Mass Spectrom. 2005 Mar;16(3):363-9. Epub 2005 Jan 19.

Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds.

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1
Eli Lilly Canada Inc., Toronto, Ontario, Canada.

Erratum in

  • J Am Soc Mass Spectrom. 2005 May;16(5):798.

Abstract

An automated nanospray system based on chip technology (the NanoMate) was successfully interfaced to a modified Particle Discriminator Interface on a triple quadrupole mass spectrometer. A number of the interface parameters were optimized to improve the sampling efficiency for ions from the chip-based system. Analytical performance was assessed using a number of biochemicals as well as via a methodology for a pharmaceutical that passed validation as required by Good Laboratory Practices. Infusion analyses in flow rates <1 microL/min provided advantages in terms of throughput and sample consumption when compared to other methodologies based on liquid chromatography.

PMID:
15734329
DOI:
10.1016/j.jasms.2004.11.018
[Indexed for MEDLINE]
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