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Trends Endocrinol Metab. 2005 Mar;16(2):35-6.

A new lipase in regulating lipid mobilization: hormone-sensitive lipase is not alone.

Author information

1
Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA. draben@jhmi.edu

Abstract

Three papers recently appeared simultaneously that identify a new triacylglycerol lipase. Zimmerman et al. identified this lipase as adipocyte triacylglycerol lipase (ATGL). Jenkins et al. identified it as the zeta-isoform of a calcium-independent phospholipase A(2) (iPLA(2)), whereas Villena et al. found this enzyme and called it desnutrin. Interestingly, if, as implied, this lipase works in concert with hormone-sensitive lipase, then our concept of regulated fatty acid mobilization from triacylglycerols will have to be revised.

PMID:
15734142
DOI:
10.1016/j.tem.2005.01.009
[Indexed for MEDLINE]

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