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Vaccine. 2005 Mar 7;23(15):1770-8.

Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming.

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CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen-Bâtiment de biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.


Plants have become, over the last ten years, a suitable alternative to microbial and animal cell factories for the production of clinically-useful, therapeutic proteins. Besides the well known advantage of low-cost and large-scale production of safe and biologically active mammalian proteins, plants also are able to perform most post-translational maturations required for biological activity and suitable pharmacokinetics of recombinant therapeutic proteins. In this short review we focus on glycosylation and proteolytic processing of plant-made pharmaceuticals during their transport through the plant cell's secretory pathway. We also address the practical implications of these important processes on the effectiveness of plant molecular pharming systems.

[Indexed for MEDLINE]

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