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Infect Immun. 2005 Mar;73(3):1886-9.

Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.

Author information

1
Department of Medicine, UMDNJ-New Jersey Medical School, 225 Warren St., Newark, NJ 07103, USA. venketvi@umdnj.edu

Abstract

We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

PMID:
15731094
PMCID:
PMC1064956
DOI:
10.1128/IAI.73.3.1886-1889.2005
[Indexed for MEDLINE]
Free PMC Article

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