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Yi Chuan. 2005 Jan;27(1):167-72.

[Progress of RNA interference mechanism].

[Article in Chinese]

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State key laboratory for biology of plant diseases and insect pests, Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100094, China.


RNA interference (RNAi) is a phenomenon that the double-stranded RNA (dsRNA) intermediates the degradation of complementary mRNA found in many organisms. This is a specifically mechanism involved in kinds of proteins to complete the interference function. Structure of siRNA affects which strand will be assembled into RISC. Another role of siRNA is directing RITS complex to bind with homologue chromosome, and then induces heterochromatinization. Although systemic silence induced by dsRNA is observed in Caenorhabditis elegans and plants, this progress is probably transmembrane protein-dependent, and mostly, the systemic silencing is controlled by multi-factors.

[Indexed for MEDLINE]

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