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Neurology. 2005 Feb 22;64(4):755-7.

Cystatin C as a risk factor for Alzheimer disease.

Author information

1
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA.

Abstract

Cystatin C, a protease inhibitor with widespread distribution, is upregulated in response to injury. Levels are elevated in the brains of patients with Alzheimer disease (AD). We compared frequencies for the CST 3 exon 1 polymorphism in patients with AD and controls. A proportional odds model indicated that the CST 3 A and APOE4 combination carried a high risk: a 14-fold elevation for men and 16-fold for women. These risks apply to risk at ages older than 64 years and to a shift in onset to ages younger than 65 years.

[Indexed for MEDLINE]

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