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Org Lett. 2005 Mar 3;7(5):835-7.

Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison.

Author information

1
Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904, USA.

Abstract

14-Azacamptothecin, a potent, water-soluble analogue of the antitumor agent camptothecin, has been prepared by a convergent synthesis. The key condensation of the AB and DE rings with concomitant formation of ring C of 14-aza CPT was carried out in two stages, the latter of which involved a radical cyclization strategy. [structure: see text].

PMID:
15727453
DOI:
10.1021/ol0400701
[Indexed for MEDLINE]

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